Narlaprevir

产品说明书

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Chemical Structure| 865466-24-6 同义名 : SCH 900518
CAS号 : 865466-24-6
货号 : A437360
分子式 : C36H61N5O7S
纯度 : 98+%
分子量 : 707.96
MDL号 : MFCD16038932
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(70.63 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Narlaprevir is a potent, selective, orally bioavailable NS3 protease inhibitor (Ki=6 nM; EC90=40 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.41mL

0.28mL

0.14mL

7.06mL

1.41mL

0.71mL

14.13mL

2.83mL

1.41mL
参考文献

[1]Zhu J, Li Y, et al. Insight into the structural requirements of narlaprevir-type inhibitors of NS3/NS4A protease based on HQSAR and molecular field analyses. Comb Chem High Throughput Screen. 2012 Jul;15(6):439-50.

[2]Ashok A, Frank B, et al. Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor. ACS Med. Chem. Lett., 2010, 1 (2), pp 64–69