SAH

产品说明书

Print
Chemical Structure| 979-92-0 同义名 : S-(5'-腺苷)-L-高半胱氨酸 ;SAH (S-Adenosylhomocysteine); S-Adenosylhomocysteine; S-(5′-Adenosyl)-L-homocysteine; Formycinylhomocysteine; AdoHcy; SAH
CAS号 : 979-92-0
货号 : A435561
分子式 : C14H20N6O5S
纯度 : 97%
分子量 : 384.41
MDL号 : MFCD00037388
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(156.08 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 S-Adenosylhomocysteine (SAH) serves as an amino acid derivative and plays a regulatory role in various metabolic pathways, acting as an intermediate in the synthesis of cysteine and adenosine[1]. It inhibits the METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.01mL

2.60mL

1.30mL

26.01mL

5.20mL

2.60mL
参考文献

[1]DE LA HABA G, et al. The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine. J Biol Chem. 1959 Mar;234(3):603-8.

[2]Li F, et al. A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5. Biomol Screen. 2016 Mar;21(3):290-7.