PRT-060318

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Chemical Structure| 1194961-19-7 同义名 : PRT318; P142-76
CAS号 : 1194961-19-7
货号 : A424910
分子式 : C18H24N6O
纯度 : 99%
分子量 : 340.42
MDL号 : MFCD28155088
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 25 mg/mL(73.44 mM)，配合低频超声助溶
生物活性
描述 PRT-060318 is a selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. It completely inhibits HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.94mL

0.59mL

0.29mL

14.69mL

2.94mL

1.47mL

29.38mL

5.88mL

2.94mL
参考文献

[1]Badolia R, Kostyak JC, Dangelmaier C, Kunapuli SP. Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling. Int J Mol Sci. 2017 Jun 9;18(6). pii: E1238.

[2]Reilly MP, Sinha U, et al. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model. Blood. 2011 Feb 17;117(7):2241-6.