Robustine

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Chemical Structure| 2255-50-7 同义名 : 8-羟基白鲜碱
CAS号 : 2255-50-7
货号 : A424850
分子式 : C12H9NO3
纯度 : 99%+
分子量 : 215.2
MDL号 : MFCD01545265
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(487.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Robustine, a natural product isolated and purified from the stem wood of Zanthoxylum avicennae., exhibits inhibition (IC 50 < or = 18.19 mM) of superoxide anion generation by human neutrophils in response to formyl- l-methionyl- l-leucyl- l-phenylalanine/cytochalasin B (FMLP/CB), suggests that it may have anti-inflammatory activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.65mL

0.93mL

0.46mL

23.23mL

4.65mL

2.32mL

46.47mL

9.29mL

4.65mL
参考文献

[1]Chen JJ, Wang TY, Hwang TL. Neolignans, a coumarinolignan, lignan derivatives, and a chromene: anti-inflammatory constituents from Zanthoxylum avicennae. J Nat Prod. 2008 Feb;71(2):212-7.

[2]Nam KW, Je KH, et al. Inhibitory effects of furoquinoline alkaloids from Melicope confusa and Dictamnus albus against human phosphodiesterase 5 (hPDE5A) in vitro. Arch Pharm Res. 2005 Jun;28(6):675-9.