Y16

产品说明书

Print
Chemical Structure| 429653-73-6 同义名 : -
CAS号 : 429653-73-6
货号 : A418195
分子式 : C24H20N2O3
纯度 : 98%
分子量 : 384.43
MDL号 : MFCD03083787
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(65.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Y16 acts as a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor (LARG) with a Kd of 76 nM. It effectively inhibits the interaction between LARG and associated G-protein-coupled Rho GEFs with RhoA. Y16 does not impact other members of the diffuse B-cell lymphoma (Dbl) family Rho GEFs, Rho effectors, or a RhoGAP[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.01mL

2.60mL

1.30mL

26.01mL

5.20mL

2.60mL
参考文献

[1]Shang X, et al. Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.