2′,2′-Difluorodeoxyuridine

产品说明书

Print
Chemical Structure| 114248-23-6 同义名 : dFdU; 2',2'-Difluoro-2'-deoxyuridine
CAS号 : 114248-23-6
货号 : A415035
分子式 : C9H10F2N2O5
纯度 : 98%
分子量 : 264.18
MDL号 : MFCD00871912
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(454.23 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(378.53 mM)，配合低频超声助溶
生物活性
描述 2′,2′-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine. Its radiosensitizing effect is concentration- and schedule-dependent in vitro[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.79mL

0.76mL

0.38mL

18.93mL

3.79mL

1.89mL

37.85mL

7.57mL

3.79mL
参考文献

[1]Pauwels B, et al. The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro. Cancer Chemother Pharmacol. 2006 Aug;58(2):219-28.