Dabigatran etexilate mesylate
产品说明书
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同义名 : | BIBR 1048MS; Dabigatran etexilate methanesulfonate; Dabigatran etexilate (mesylate); Pradaxa |
| CAS号 : | 872728-81-9 | |
| 货号 : | A412174 | |
| 分子式 : | C35H45N7O8S | |
| 纯度 : | 98% | |
| 分子量 : | 723.84 | |
| MDL号 : | MFCD25424070 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 25 mg/mL(34.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Dabigatran etexilate mesylate is the orally active prodrug of dabigatran, a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02171572 | Healthy | Phase 1 | Completed | - | - |
| NCT02904499 | - | Completed | - | France ... 展开 >> University Hospital of Reunion Island Saint Denis, Reunion Island, France, 97400 收起 << | |
| NCT02921126 | - | Completed | - | Italy ... 展开 >> Local Institution Ravenna, Italy, 48121 收起 << | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.38mL 0.28mL 0.14mL |
6.91mL 1.38mL 0.69mL |
13.82mL 2.76mL 1.38mL |
| 参考文献 |
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