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Chemical Structure| 1642288-47-8 同义名 : -
CAS号 : 1642288-47-8
货号 : A409555
分子式 : C15H19N3O2
纯度 : 99%
分子量 : 273.33
MDL号 : MFCD31746877
存储条件：

Pure form Keep in dark place, sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(310.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 MYK-461 is a myosin inhibitor potentially for the treatment of hypertrophic cardiomyopathy, and can reduce contractility by decreasing the adenosine triphosphatase activity of the cardiac myosin heavy chain.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.66mL

0.73mL

0.37mL

18.29mL

3.66mL

1.83mL

36.59mL

7.32mL

3.66mL
参考文献

[1]Kawas RF, Anderson RL, et al. A small molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Aug 14. pii: jbc.M117.776815.

[2]Green EM, Wakimoto H, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351(6273):617-21.