Seltorexant

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Chemical Structure| 1293281-49-8 同义名 : JNJ-42847922
CAS号 : 1293281-49-8
货号 : A407757
分子式 : C21H22FN7O
纯度 : 99% （cis）
分子量 : 407.44
MDL号 : MFCD31700700
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(61.36 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Seltorexant is a selective orexin-2 receptor antagonist that has been shown to promote sleep in various species.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.25mL

12.27mL

2.45mL

1.23mL

24.54mL

4.91mL

2.45mL
参考文献

[1]Bonaventure P, Shelton J, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82.

[2]Letavic MA, Bonaventure P, et al. Novel Octahydropyrrolo[3,4-c] pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate. J Med Chem. 2015 Jul 23;58(14):5620-36.