LF3
产品说明书
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同义名 : | - |
| CAS号 : | 664969-54-4 | |
| 货号 : | A406788 | |
| 分子式 : | C20H24N4O2S2 | |
| 纯度 : | 99% | |
| 分子量 : | 416.56 | |
| MDL号 : | MFCD03352482 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(600.15 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | LF3 inhibits Wnt/β-catenin signaling in cells with exogenous reporter genes and in colorectal cancer cells with high intrinsic Wnt activity, with IC50 values of 1.65 μM (β-Catenin/TCF4, AlphaScreen) and 1.82 μM (β-Catenin/TCF4, ELISA). LF3 also suppresses cancer cell traits associated with Wnt signaling, including high cell motility, cell cycle progression, and overexpression of Wnt target genes. However, LF3 does not induce cell death or interfere with cadherin-mediated cell adhesion. Notably, the self-renewal capacity of cancer stem cells is blocked by LF3 in a concentration-dependent manner[1]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02683616 | Obstructive Sleep Apnea ... 展开 >> Fatty Acid Metabolism Continuous Positive Airway Pressure 收起 << | Not Applicable | Recruiting | December 2019 | Czechia ... 展开 >> FN Kralovske Vinohrady Recruiting Prague, Czechia, 10034 Contact: Jan Polak, MD, PhD +420267162710 jan.polak@lf3.cuni.cz Contact: Jan Gojda, MD, PhD +420267168144 jan.gojda@lf3.cuni.cz 收起 << |
| NCT03710850 | Insulin Resistance ... 展开 >> Microbiome 收起 << | Not Applicable | Recruiting | December 31, 2021 | Czechia ... 展开 >> University Hospital Kralovske Vinohrady Recruiting Prague, Czechia, 10084 Contact: Jana Potočková +420267163031 klinicka.fyziologie@lf3.cuni.cz 收起 << |
| NCT03386461 | Metabolism Disorder ... 展开 >> Adiposity Inflammatory Response 收起 << | Not Applicable | Recruiting | December 2019 | Czechia ... 展开 >> Third Faculty of Medicine, Charles University Recruiting Prague, Czechia, 100 00 Contact: Michaela Siklova, PhD +420 267 102 211 michaela.siklova@lf3.cuni.cz Contact: Lenka Rossmeislova, PhD +420 267 102 211 lenka.rossmeislova@lf3.cuni.cz Principal Investigator: Michaela Siklova, PhD Sub-Investigator: Martin Rossmeisl, PhD Sub-Investigator: Vladimir Stich, prof. MUDr. 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.40mL 0.48mL 0.24mL |
12.00mL 2.40mL 1.20mL |
24.01mL 4.80mL 2.40mL |
| 参考文献 |
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