PRX-08066 maleate

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Chemical Structure| 866206-55-5 同义名 : PRX-08066 Maleic acid
CAS号 : 866206-55-5
货号 : A403363
分子式 : C23H21ClFN5O4S
纯度 : 98+%
分子量 : 517.96
MDL号 : MFCD23704188
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
靶点

  • 5-HT2

    5-HT2B, IC50:3.4 nM
描述 PRX-08066 maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.65mL

1.93mL

0.97mL

19.31mL

3.86mL

1.93mL
参考文献

[1]Porvasnik SL, Germain S, et al. PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. J Pharmacol Exp Ther. 2010 Aug;334(2):364-72.

[2]Svejda B, Kidd M, et al. The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. Cancer. 2010 Jun 15;116(12):2902-12.