MK-8745

产品说明书

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Chemical Structure| 885325-71-3 同义名 : -
CAS号 : 885325-71-3
货号 : A401505
分子式 : C20H19ClFN5OS
纯度 : 99+%
分子量 : 431.91
MDL号 : MFCD28009367
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(243.1 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Aurora A

    Aurora A, IC50:0.6 nM
描述 MK-8745 is a potent and selective Aurora an inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.58mL

2.32mL

1.16mL

23.15mL

4.63mL

2.32mL
参考文献

[1]Chowdhury A, Chowdhury S, et al. A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell lines. Leuk Lymphoma. 2012 Mar;53(3):462-71.

[2]Nair JS, Ho AL, et al. The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent. Cell Cycle. 2012 Feb 15;11(4):807-17.