4',5-Dihydroxy-7-methoxyflavone

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Chemical Structure| 437-64-9 同义名 : Puddumetin; Genkwanin; 7-Methylapigenin; Apigenin 7-methyl ether
CAS号 : 437-64-9
货号 : A400206
分子式 : C16H12O5
纯度 : 99%+
分子量 : 284.26
MDL号 : MFCD00017452
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(105.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Genkwanin, a natural product isolated and purified from the herbs of Lobelia chinensis, exerts its anti-inflammatory effect mainly through the regulation of the miR-101/MKP-1/MAPK pathway, and is transported by both passive diffusion and multidrug resistance protein (MDR)-mediated efflux mechanisms.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.18mL

7.04mL

3.52mL
参考文献

[1]Gao Y, Liu F, et al. Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages. PLoS One. 2014 May 6;9(5):e96741.

[2]Jiang CP, He X, et al. Intestinal absorptive transport of Genkwanin from Flos genkwa using a single-pass intestinal perfusion rat model. Am J Chin Med. 2014;42(2):349-59.