Endoxifen E-isomer HCl

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Chemical Structure| 1197194-61-8 同义名 : E-Endoxifen hydrochloride; Endoxifen E-isomer hydrochloride
CAS号 : 1197194-61-8
货号 : A397546
分子式 : C25H28ClNO2
纯度 : 99%+
分子量 : 409.95
MDL号 : MFCD29924733
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(73.18 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 The E-isomer of Endoxifen hydrochloride (E-Endoxifen hydrochloride), known as an impurity in the Z-isomer of Endoxifen, also exhibits antiestrogenic properties[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.20mL

2.44mL

1.22mL

24.39mL

4.88mL

2.44mL
参考文献

[1]Elkins P, et, al. Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC⬜MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9.

[2]Zheng Y, et, al. Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. Drug Metab Dispos. 2007 Oct;35(10):1942-8.