Rhapontigenin

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Chemical Structure| 500-65-2 同义名 : Protigenin
CAS号 : 500-65-2
货号 : A397389
分子式 : C15H14O4
纯度 : 99%+
分子量 : 258.27
MDL号 : MFCD00017718
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(464.63 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Rhapontigenin, a natural product isolated and purified from the rhizomes of Rheum undulatum with antioxidative, antihyperlipidemic, and antifungal activities, inhibits tyrosinase activity and melanin synthesis in B16F10 melanoma cells and HIF-1α accumulation and angiogenesis in PC-3 prostate cancer cells, suppresses breast cancer cell migration and invasion, which is involved in inhibiting the PI3K-dependent Rac1 signaling pathway.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.87mL

0.77mL

0.39mL

19.36mL

3.87mL

1.94mL

38.72mL

7.74mL

3.87mL
参考文献

[1]Jo SP, Kim JK, Lim YH. Antihyperlipidemic effects of rhapontin and rhapontigenin from rheum undulatum in rats fed a high-cholesterol diet. Planta Med. 2014 Aug;80(13):1067-71.

[2]Kim N, Kim JK, et al. The possible mechanism of rhapontigenin influencing antifungal activity on Candida albicans. Med Mycol. 2013 Jan;51(1):45-52.