Rofecoxib

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Chemical Structure| 162011-90-7
CAS号 : 162011-90-7
货号 : A395001
分子式 : C17H14O4S
纯度 : 98%
分子量 : 314.36
MDL号 : MFCD00935806
存储条件：

Pure form Sealed in dry, 2-8°C
参考文献

[1]Karjalainen MJ, Neuvonen PJ, et al. Rofecoxib is a potent, metabolism-dependent inhibitor of CYP1A2: implications for in vitro prediction of drug interactions. Drug Metab Dispos. 2006 Dec;34(12):2091-6. Epub 2006 Sep 19.

[2]Chan CC, Boyce S, et al. Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone] : a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther. 1999 Aug;290(2):551-60.

[3]Chan CC, Boyce S, Brideau C, et al. Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. J Pharmacol Exp Ther. 1999;290(2):551-560

[4]Liu NN, Sun YZ, Zhao N, Chen L. Rofecoxib inhibits retinal neovascularization via down regulation of cyclooxygenase-2 and vascular endothelial growth factor expression. Clin Exp Ophthalmol. 2015;43(5):458-465

[5]Stoppoloni D, Canino C, Cardillo I, et al. Synergistic effect of gefitinib and rofecoxib in mesothelioma cells. Mol Cancer. 2010;9:27. Published 2010 Feb 2