β,β-Dimethylacrylshikonin

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Chemical Structure| 24502-79-2 同义名 : Dimethylacrylshikonin; Isoarnebin I
CAS号 : 24502-79-2
货号 : A393692
分子式 : C21H22O6
纯度 : 99%+
分子量 : 370.4
MDL号 : MFCD00143687
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(32.4 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Dimethylacrylshikonin, a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc. with anti-proliferate activity, is a promising agent for developing an improved strategy for radiotherapy against tumors.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.70mL

0.54mL

0.27mL

13.50mL

2.70mL

1.35mL

27.00mL

5.40mL

2.70mL
参考文献

[1]Kwak SY, Jeong YK, et al. β,β-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species. Oncol Lett. 2014 Jun;7(6):1812-1818.

[2]Wu YY, Wan LH, et al. Inhibitory effects of β,β-dimethylacrylshikonin on hepatocellular carcinoma in vitro and in vivo. Phytother Res. 2012 May;26(5):764-71.