DBeQ
产品说明书
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同义名 : | JRF 12; N,N'-Dibenzylquinazoline-2,4-diamine |
| CAS号 : | 177355-84-9 | |
| 货号 : | A391735 | |
| 分子式 : | C22H20N4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 340.42 | |
| MDL号 : | MFCD03691820 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(102.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
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| 靶点 |
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| 描述 | P97 ATPase, which is also known as VCP (valosin-containing protein) or TERA (translational endoplasmic reticulum ATPase), has various substrates,such as LC3,HIF1A, CYP3a. It is involved in autophagy, ERAD pathway etc.. DBeQ can inhibit p97 selectively and potently in a reversible and ATP-competitive manner. Different from the conventional proteasome inhibitors, DBeQ affects both the UPS and autophagic protein degradation pathways. DBeQ can also rapidly activate caspases 3/7 and induce cell death, which target p97 in cancer therapy[1]. | ||
| 作用机制 | DBeQ binds to the active site of the D2 domain and inhibits p97 in an ATP-competition manner.[1] | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.94mL 0.59mL 0.29mL |
14.69mL 2.94mL 1.47mL |
29.38mL 5.88mL 2.94mL |
