Tinoridine HCl

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Chemical Structure| 25913-34-2 同义名 : Y-3642 HCl; Y-3642 hydrochloride; Tinoridine hydrochloride
CAS号 : 25913-34-2
货号 : A388367
分子式 : C17H21ClN2O2S
纯度 : 99%+
分子量 : 352.88
MDL号 : MFCD01680536
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(45.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2.5 mg/mL(7.08 mM)，配合低频超声，并水浴加热至45℃助溶
生物活性
描述 Active oxygen species have been implicated in a variety of pathophysiological conditions, such as inflammation, aging, hepatotoxicity and ischemic brain and myocardium damage. Tinoridine, a non-steroidal anti-inflammatory drug, inhibits the lipid peroxidation in rat liver microsomes and mitochondria. The anti-peroxidative activity of tinoridine has been suggested to contribute to its membrane stabilizing activity demonstrated on various biomembranes. Tinoridine reduced a stable free radical, diphenyl-p-picrylhydrazyl, in the molar ratio of about 1∶2, indicating its free radical scavenging ability. Tinoridine inhibited the lipid peroxidation in rat liver microsomes induced by xanthine-xanthine oxidase system in the presence of ADP and Fe2+, in which hydroxyl radical (•OH) is formed. These results indicate that tinoridine is able to scavenge •OH and the main active oxygen species responsible for the lipid peroxidation is •OH[1]. In addition, the administration of tinoridine (100 mg/kg) to rats prevented the CCl4-induced hepatotoxicity, in which the lipid peroxidation in microsomes caused by CC14 is suggested to have a decisive role[2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01224756 Pain Inflamma... 展开 >>tion 收起 << Phase 4 Completed - Indonesia ... 展开 >> Semarang, Central Java, Indonesia Jakarta, DKI Jakarta, Indonesia Surabaya, East Java, Indonesia Bandung, West Java, Indonesia 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.17mL

2.83mL

1.42mL

28.34mL

5.67mL

2.83mL
参考文献

[1]Hydroxyl radical scavenging action of tinoridine

[2]Yasuda H, Izumi N, Shimada O, Kobayakawa T, Nakanishi M. The protective effect of tinoridine against carbon tetrachloride hepatotoxicity. Toxicol Appl Pharmacol. 1980;52(3):407‐413