Sotalol HCl

产品说明书

Print
Chemical Structure| 959-24-0 同义名 : MJ 1999; Sotalol (hydrochloride); Sotalol hydrochloride
CAS号 : 959-24-0
货号 : A386508
分子式 : C12H21ClN2O3S
纯度 : 95+%
分子量 : 308.82
MDL号 : MFCD00242937
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(340 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(323.81 mM)
动物实验配方：

PO 0.5% CMC-Na 80 mg/mL clear

生物活性
靶点

  • β-adrenergic receptor
描述 Sotalol hydrochloride is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.24mL

0.65mL

0.32mL

16.19mL

3.24mL

1.62mL

32.38mL

6.48mL

3.24mL
参考文献

[1]Kulmatycki KM, Abouchehade K, et al. Drug-disease interactions: reduced beta-adrenergic and potassium channel antagonist activities of sotalol in the presence of acute and chronic inflammatory conditions in the rat. Br J Pharmacol. 2001 May;133(2):286-94.

[2]Antonaccio MJ, Gomoll A. Pharmacologic basis of the antiarrhythmic and hemodynamic effects of sotalol. Am J Cardiol. 1993 Aug 12;72(4):27A-37A.