DG051

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Chemical Structure| 929915-58-2 同义名 : -
CAS号 : 929915-58-2
货号 : A385038
分子式 : C21H25Cl2NO4
纯度 : 98%
分子量 : 426.33
MDL号 : MFCD18251532
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 300 mg/mL(703.67 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 DG051 is a potent leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis in the enzyme assay with an IC50=47 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.35mL

0.47mL

0.23mL

11.73mL

2.35mL

1.17mL

23.46mL

4.69mL

2.35mL
参考文献

[1]Sandanayaka V, Mamat B, et al. Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy] methyl}-1-pyrrolidinyl] butanoic acid(DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. J Med Chem. 2010 Jan 28;53(2):573-85.

[2]Enache LA, Zhang J, et al. Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6275-9.