Zotarolimus

产品说明书

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Chemical Structure| 221877-54-9 同义名 : 佐罗莫司 ;ABT-578; A 179578; Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-.; Endeavor
CAS号 : 221877-54-9
货号 : A381503
分子式 : C52H79N5O12
纯度 : 98%
分子量 : 966.21
MDL号 : MFCD09752954
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(108.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • mTOR

    FKBP-12, IC50:2.8 nM
描述 Zotarolimus is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.03mL

0.21mL

0.10mL

5.17mL

1.03mL

0.52mL

10.35mL

2.07mL

1.03mL
参考文献

[1]Chen YW, Smith ML, et al. Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression. J Cardiovasc Pharmacol. 2007 Apr;49(4):228-35.

[2]Garcia-Touchard A, Burke SE, et al. Zotarolimus-eluting stents reduce experimental coronary artery neointimal hyperplasia after 4 weeks. Eur Heart J. 2006 Apr;27(8):988-93. Epub 2006 Jan 31.