TCS 359

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Chemical Structure| 301305-73-7 同义名 : FLT3 Inhibitor; Fms-like Tyrosine Kinase Inhibitor; TCS359, TCS 359, TCS-359, Flt-3 inhibitor
CAS号 : 301305-73-7
货号 : A374354
分子式 : C18H20N2O4S
纯度 : 99%+
分子量 : 360.43
MDL号 : MFCD00617269
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 15 mg/mL(41.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 TCS 359, a 2-acylaminothiophene-3-carboxamide, serves as a potent and selective FLT3 inhibitor with an IC50 of 42 nM. It also suppresses MV4-11 cell proliferation with an IC50 of 340 nM [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.87mL

2.77mL

1.39mL

27.74mL

5.55mL

2.77mL
参考文献

[1]Patch RJ, et al. Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3282-6.