Enalaprilat

产品说明书

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Chemical Structure| 76420-72-9 同义名 : MK-422 anhydrous
CAS号 : 76420-72-9
货号 : A373644
分子式 : C18H24N2O5
纯度 : 98%
分子量 : 348.39
MDL号 : MFCD00865786
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Enalaprilat (MK-422 anhydrous), the active metabolite of Enalapril, is a highly effective, competitive, and long-lasting inhibitor of the angiotensin-converting enzyme (ACE), with an IC50 of 1.94 nM. It is particularly used in the research of hypertension[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.87mL

0.57mL

0.29mL

14.35mL

2.87mL

1.44mL

28.70mL

5.74mL

2.87mL
参考文献

[1]Ceconi C, et, al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6.

[2]Eickels M, et, al. Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol. 2000 Dec;131(8):1592-6.

[3]Loftsson T, et, al. Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits. Acta Ophthalmol. 2010 May;88(3):337-41.