Lodoxamide

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Chemical Structure| 53882-12-5 同义名 : U-42585E free acid
CAS号 : 53882-12-5
货号 : A370864
分子式 : C11H6ClN3O6
纯度 : 98%+
分子量 : 311.63
MDL号 : MFCD00864803
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(160.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Lodoxamide blocks histamine release induced by compound 48/80 and inhibits ionophore-induced 45Ca influx along with associated histamine release in purified rat peritoneal mast cells[1]. Lodoxamide significantly and dose-dependently reduces the chemotactic response of eosinophils to fMLP and IL-5. It also strongly inhibits the release of eosinophil peroxidase following IgA-dependent activation and, to a lesser extent, inhibits the release of eosinophil cationic protein and eosinophil-derived neurotoxin[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.21mL

0.64mL

0.32mL

16.04mL

3.21mL

1.60mL

32.09mL

6.42mL

3.21mL
参考文献

[1]Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286-94.

[2]Capron M,et al. Inhibitory effects of lodoxamide on eosinophil activation. Int Arch Allergy Immunol. 1998 Jun;116(2):140-6.

[3]Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115(3):631-6; discussion 636-7.

[4]Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76(1):83-90.