XL413 HCl

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Chemical Structure| 1169562-71-3 同义名 : BMS-863233; XL413; BMS-863233 hydrochloride
CAS号 : 1169562-71-3
货号 : A368616
分子式 : C14H13Cl2N3O2
纯度 : 99%+
分子量 : 326.18
MDL号 : MFCD28023577
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
靶点

  • Cdc

    Cdc7, IC50:3.4 nM
描述 XL413 (BMS-863233) hydrochloride is an orally active and selective CDC7 inhibitor (IC50=3.4 nM). XL413 hydrochloride exhibits favorable pharmacokinetic profiles and effectively suppresses tumor growth in rodent models. XL413 hydrochloride serves as a valuable tool in cancer research [1].
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
Caco2 cells Function assay Induction of apoptosis in human Caco2 cells assessed as increase in caspase 3/7 activity, EC50=2.288 μM 22560567
human Caco2 cells Function assay 4 h Inhibition of CDC7 in human Caco2 cells assessed as inhibition of MCM2 phosphorylation at Ser53 after 4 hrs, IC50=0.14 μM 22560567
human Caco2 cells Proliferation assay Antiproliferative activity against human Caco2 cells assessed as inhibition of anchorage-independent growth in soft agar, IC50=0.715 μM 22560567
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.07mL

0.61mL

0.31mL

15.33mL

3.07mL

1.53mL

30.66mL

6.13mL

3.07mL
参考文献

[1]Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. doi: 10.1016/j.bmcl.2012.04.024. Epub 2012 Apr 16. Erratum in: Bioorg Med Chem Lett. 2012 Aug 1;22(15):5157.