Tiplaxtinin

产品说明书

Print
Chemical Structure| 393105-53-8 同义名 : PAI-039; Tiplasinin
CAS号 : 393105-53-8
货号 : A363712
分子式 : C24H16F3NO4
纯度 : 98%
分子量 : 439.38
MDL号 : MFCD09475615
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(238.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.38mL

2.28mL

1.14mL

22.76mL

4.55mL

2.28mL
参考文献

[1]Krause MP, Moradi J, et al. Inhibition of plasminogen activator inhibitor-1 restores skeletal muscle regeneration in untreated type 1 diabetic mice. Diabetes. 2011 Jul;60(7):1964-72.

[2]Elokdah H, Abou-Gharbia M, et al. Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem. 2004 Jul 1;47(14):3491-4.