Glutaminase C-IN-1

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Chemical Structure| 311795-38-7 同义名 : Compound 968; Glutaminase Inhibitor Compound 968; GLS inhibitor 968; Glutaminase inhibitor-968; GLS-IN-968
CAS号 : 311795-38-7
货号 : A360888
分子式 : C27H27BrN2O
纯度 : 99%+
分子量 : 475.42
MDL号 : MFCD00606231
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(52.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Glutaminase C-IN-1, an allosteric inhibitor of Glutaminase C, suppresses the growth of cancer cells without impacting their normal cellular counterparts[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.10mL

0.42mL

0.21mL

10.52mL

2.10mL

1.05mL

21.03mL

4.21mL

2.10mL
参考文献

[1]Wang JB, et al. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010 Sep 14;18(3):207-19.

[2]Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9.