Daclatasvir

产品说明书

Print
Chemical Structure| 1009119-64-5 同义名 : 达卡他韦 ;BMS-790052; EBP 883
CAS号 : 1009119-64-5
货号 : A358801
分子式 : C40H50N8O6
纯度 : 98%
分子量 : 738.88
MDL号 : MFCD17129086
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(54.14 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • HCV Protease

    HCV NS5A, EC50:9 pM-50 pM
描述 Daclatasvir is a first-in-class, highly-selective oral HCV NS5A inhibitor.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
african green monkey Vero cells Cytotoxicity assay Cytotoxicity against african green monkey Vero cells, CC50=9.6 μM 23466233
human CEM cells Cytotoxicity assay 3 days Cytotoxicity against human CEM cells after 3 days, CC50=9.6 μM 25154714
human CEM cells Cytotoxicity assay Cytotoxicity against human CEM cells, CC50=9.6 μM 22704887
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02095860 Hepatitis C Phase 1 Completed - United States, Texas ... 展开 >> Healthcare Discoveries, Llc D/B/A Icon Development Solutions San Antonio, Texas, United States, 78209 收起 <<
NCT02531269 - Completed - Switzerland ... 展开 >> Local Institution Basel, Switzerland 收起 <<
NCT03186313 Hepatitis C Phase 3 Completed - Egypt ... 展开 >> Egyptian Liver Hospital Shirbīn, Dakahlia, Egypt, 35681 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.35mL

0.27mL

0.14mL

6.77mL

1.35mL

0.68mL

13.53mL

2.71mL

1.35mL
参考文献

[1]Lee C, Ma H, et al. The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein. Virology. 2011 May 25;414(1):10-8.

[2]Gao M, Nettles RE, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010 May 6;465(7294):96-100.