2-Hydroxy-3-methylbutanoic acid

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Chemical Structure| 4026-18-0 同义名 : -
CAS号 : 4026-18-0
货号 : A356201
分子式 : C5H10O3
纯度 : 97%
分子量 : 118.13
MDL号 : MFCD00004242
存储条件:

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(888.84 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 2-Hydroxy-3-methylbutanoic acid is a close structure analogue of GHB (gamma-hydroxybutyrate), which is a naturally occurring neurotransmitter and a psychoactive drug[1]. A method for the quantitative determination of 2-hydroxy-3-methylbutanoic (2OH3MB) has been optimized, validated and applied to a set of wines and other alcoholic beverages. Concentrations ranged from the method detection limits to 519 μg/L for 2OH3MB, which may have relevant sensory effects. 2OH3MB was not found in distillates but was present in beer. 2OH2MB, 3OH3MB and 3OHB were found in unfermented grape derivatives[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.47mL

1.69mL

0.85mL

42.33mL

8.47mL

4.23mL

84.65mL

16.93mL

8.47mL

参考文献

[1]Pan YM, Gill GN, Tilson CS, Wall WH, McCurdy HH. Improved procedure for the analysis of gamma-hydroxybutyrate and ethylene glycol in whole blood. J Anal Toxicol. 2001;25(5):328-332

[2]Gracia-Moreno E, Lopez R, Ferreira V. Quantitative determination of five hydroxy acids, precursors of relevant wine aroma compounds in wine and other alcoholic beverages. Anal Bioanal Chem. 2015;407(26):7925-7934