Yangambin

产品说明书

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Chemical Structure| 13060-14-5 同义名 : -
CAS号 : 13060-14-5
货号 : A356142
分子式 : C24H30O8
纯度 : 98%
分子量 : 446.49
MDL号 : MFCD04307767
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Yangambin, a natural product isolated and purified from the leaves of Ocotea duckei Vattimo., is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF) and therefore constitutes a potential therapeutic agent in different shock states where abnormal PAF release is supposed to play an important role. Yangambin has central nervous system activity, presenting a depressant activity in the open field, forced swimming and pentobarbital sleeping time tests, and hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibition the Ca2+ influx through voltage-gated Ca2+ channels.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.20mL

2.24mL

1.12mL

22.40mL

4.48mL

2.24mL
参考文献

[1]Araujo IG, Silva DF, et al. Calcium influx inhibition is involved in the hypotensive and vasorelaxant effects induced by yangambin. Molecules. 2014 May 23;19(5):6863-76.

[2]Monte Neto RL, Sousa LM, et al. Morphological and physiological changes in Leishmania promastigotes induced by yangambin, a lignan obtained from Ocotea duckei. Exp Parasitol. 2011 Jan;127(1):215-21.