IEM-1754

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Chemical Structure| 162831-31-4 同义名 : IEM 1754 2HBr
CAS号 : 162831-31-4
货号 : A354848
分子式 : C16H32Br2N2
纯度 : 99%
分子量 : 412.25
MDL号 : MFCD03105050
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(254.7 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • AMPA receptor

    GluR1, IC50:6 μM

    GluR3, IC50:6 μM
描述 IEM 1754 dihydrobromide is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.43mL

0.49mL

0.24mL

12.13mL

2.43mL

1.21mL

24.26mL

4.85mL

2.43mL
参考文献

[1]Tikhonov DB, Samoilova MV, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74.

[2]Magazanik LG, Buldakova SL, et al. Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J Physiol. 1997 Dec 15;505 ( Pt 3):655-63.