Nicotiflorin
产品说明书
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同义名 : | 山奈酚-3-O-芸香糖苷 ;Kaempferol-3-O-rutinoside; 3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside; Kaempferol 3-O-β-rutinoside; Nikotoflorin |
| CAS号 : | 17650-84-9 | |
| 货号 : | A347566 | |
| 分子式 : | C27H30O15 | |
| 纯度 : | 99%+ | |
| 分子量 : | 594.52 | |
| MDL号 : | MFCD03427292 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(420.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Nicotiflorin is a single component extracted from traditional Chinese medicine Flos Carthami. At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduced brain infarct volume and neurological deficits. For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuated cell death and reduced LDH release[3]. In vivo, nicotiflorin treatment alleviated brain damage and neurological deficit while it dramatically increased 72 h survival rate in rats. In vitro, nicotiflorin treatment also ameliorated the severity of OGD/R(oxygen-glucose deprivation and reintroduction). In vitro, nicotiflorin likewise enhanced autophagy and promoted autophagy flux[4]. Nicotiflorin (10 mg/kg) protects against cerebral ischemia/reperfusion injury-induced apoptosis via the JAK2/STAT3 pathway[5]. Nicotiflorin and rutin showed neuroprotective effects on hypoxia-, glutamate- or oxidative stress-induced RGC (retinal ganglion cell) death at concentrations of 1 nM or higher[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.68mL 0.34mL 0.17mL |
8.41mL 1.68mL 0.84mL |
16.82mL 3.36mL 1.68mL |
| 参考文献 |
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