CNX-2006

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Chemical Structure| 1375465-09-0 同义名 : -
CAS号 : 1375465-09-0
货号 : A346385
分子式 : C26H27F4N7O2
纯度 : 99%
分子量 : 545.53
MDL号 : MFCD26142654
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(91.65 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • EGFR/ErbB1

    mutant EGFR, IC50:<20 nM

  • mutant EGFR

    mutant EGFR, IC50:<20 nM
描述 CNX-2006 is an irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.83mL

0.37mL

0.18mL

9.17mL

1.83mL

0.92mL

18.33mL

3.67mL

1.83mL
参考文献

[1]Mizuuchi H, Suda K, et al. Oncogene swap as a novel mechanism of acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor in lung cancer. Cancer Sci. 2016 Apr;107(4):461-8.

[2]Galvani E, Sun J, et al. NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor. Oncotarget. 2015 Dec 15;6(40):42717-32.