Cyclothiazide

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Chemical Structure| 2259-96-3 同义名 : Doburil
CAS号 : 2259-96-3
货号 : A343078
分子式 : C14H16ClN3O4S2
纯度 : 95% (mixture of isomers)
分子量 : 389.88
MDL号 : MFCD00210192
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(307.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Cyclothiazide acts as a positive allosteric modulator for AMPA receptors and is commonly employed to prevent the desensitization of AMPA receptors, whether they are native or expressed in a heterologous system. It is recognized for its rapid inhibition of desensitization in AMPA receptors and a more gradual enhancement of AMPA-mediated currents[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.56mL

0.51mL

0.26mL

12.82mL

2.56mL

1.28mL

25.65mL

5.13mL

2.56mL
参考文献

[1]Fucile S, et al. Effects of cyclothiazide on GluR1/AMPA receptors. Proc Natl Acad Sci U S A. 2006;103(8):2943-2947.