Vindoline

产品说明书

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Chemical Structure| 2182-14-1 同义名 : 文朵灵 ;NSC 91994
CAS号 : 2182-14-1
货号 : A341153
分子式 : C25H32N2O6
纯度 : 99%
分子量 : 456.53
MDL号 : MFCD27991347
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(567.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Vindoline is a natural product isolated and purified from the herbs of Catharanthus roseus (L.) G. Don which can regulate the glucose-stimulated insulin secretion (GSIS), may contribute to the anti-diabetic effects of Catharanthus roseus, and this natural product may find its more applications in the improvement of β-cell dysfunction and further the potential treatment of type 2 diabetes.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.95mL

2.19mL

1.10mL

21.90mL

4.38mL

2.19mL
参考文献

[1]Zhou P, Yang J, et al. Effects of β-cyclodextrin and methyl jasmonate on the production of vindoline, catharanthine, and ajmalicine in Catharanthus roseus cambial meristematic cell cultures. Appl Microbiol Biotechnol. 2015 Sep;99(17):7035-45.

[2]Qu Y, Easson ML, et al. Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast. Proc Natl Acad Sci U S A. 2015 May 12;112(19):6224-9.