B7/CD28 interaction inhibitor 1

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Chemical Structure| 635324-72-0 同义名 : -
CAS号 : 635324-72-0
货号 : A338124
分子式 : C21H13F4N5O
纯度 : 96%
分子量 : 427.35
MDL号 : MFCD28127008
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(140.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases. B7/CD28 interaction inhibitor 1 is a potent small molecule inhibitor of the B7.1-CD28 interaction with an IC50 of 50 nM[2].
作用机制 B7/CD28 interaction inhibitor 1 binds to the V-like domain of human B7.1[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.34mL

0.47mL

0.23mL

11.70mL

2.34mL

1.17mL

23.40mL

4.68mL

2.34mL
参考文献

[1]Green NJ, et al. Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1. Bioorg Med Chem. 2003 Jul 3;11(13):2991-3013.

[2]Green NJ, et al. Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1. Bioorg Med Chem. 2003 Jul 3;11(13):2991-3013