Obicetrapib

产品说明书

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Chemical Structure| 866399-87-3 同义名 : -
CAS号 : 866399-87-3
货号 : A329677
分子式 : C32H31F9N4O5
纯度 : 98+%
分子量 : 722.6
MDL号 : MFCD30533470
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Obicetrapib is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.38mL

0.28mL

0.14mL

6.92mL

1.38mL

0.69mL

13.84mL

2.77mL

1.38mL
参考文献

[1]van Capelleveen JC, Kastelein JJ, et al. Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses. J Clin Lipidol. 2016 Sep-Oct;10(5):1137-1144.e3.

[2]Hovingh GK, Kastelein JJ, et al. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet. 2015 Aug 1;386(9992):452-60.