Edrophonium chloride
产品说明书
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同义名 : | 氯化依地膦 ;Edrophonium (chloride); Reversol; Enlon; Antirex; Tensilon chloride; Tensilon |
| CAS号 : | 116-38-1 | |
| 货号 : | A329103 | |
| 分子式 : | C10H16ClNO | |
| 纯度 : | 98% | |
| 分子量 : | 201.69 | |
| MDL号 : | MFCD00055064 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 60 mg/mL(297.48 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Edrophonium chloride is an acetylcholinesterase inhibitor with a rapid onset (approximately 30 seconds) and short duration (approximately 5 minutes). The edrophonium challenge test may be useful for diagnosing cervical dystonia[3]. After low doses of edrophonium (1.0 mumol/kg) there was a significant correlation between the monophasic potentiation of twitch tension and the plasma concentration of the drug[4]. Moreover, electrophysiological effects of edrophonium in man are mediated primarily through autonomic innervation of the heart[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01758692 | - | Recruiting | June 2021 | United States, New York ... 展开 >> James J Peters VA Medical Center Recruiting Bronx, New York, United States, 10468 Contact: Jill M Wecht, Ed.D 718-584-9000 ext 3122 jm.wecht@va.gov Contact: Matthew T Maher, MS 7185849000 ext 1706 matthew.maher@va.gov Principal Investigator: Jill M Wecht, Ed.D. Sub-Investigator: Gregory Schilero, M.D. Sub-Investigator: Miroslav Radulovic, M.D. Sub-Investigator: William A Bauman, M.D. 收起 << | |
| NCT00359346 | - | Completed | - | United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 << | |
| NCT02944175 | Supratentorial Brain Tumor Sur... 展开 >>gery 收起 << | Not Applicable | Enrolling by invitation | October 1, 2019 | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.96mL 0.99mL 0.50mL |
24.79mL 4.96mL 2.48mL |
49.58mL 9.92mL 4.96mL |
| 参考文献 |
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[2]NEW and nonofficial remedies: edrophonium chloride. J Am Med Assoc. 1953 Aug 29;152(18):1714-5. |