Fleroxacin

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Chemical Structure| 79660-72-3 同义名 : RO 23-6240; AM-833; Fleroxacin, Quinodis, Megalocin, AM-833, Ro 236240
CAS号 : 79660-72-3
货号 : A328492
分子式 : C17H18F3N3O3
纯度 : 98+%
分子量 : 369.34
MDL号 : MFCD00864880
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 30 mg/mL(81.23 mM)，配合低频超声，并调节pH至11

0.1 M NaOH: 8 mg/mL(21.66 mM)，配合低频超声，并调节pH至11
生物活性
描述 Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03600480 Obesity Overw... 展开 >>eight 收起 << Phase 1 Recruiting January 22, 2020 United States, Kansas ... 展开 >> Novo Nordisk Investigational Site Recruiting Overland Park, Kansas, United States, 66212 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.54mL

2.71mL

1.35mL

27.08mL

5.42mL

2.71mL
参考文献

[1]MacDonald KS, Cameron DW, et al. Evaluation of fleroxacin (RO 23-6240) as single-oral-dose therapy of culture-proven chancroid in Nairobi, Kenya. Antimicrob Agents Chemother. 1989 May;33(5):612-4.

[2]Weidekamm E, Portmann R, et al. Single- and multiple-dose pharmacokinetics of fleroxacin, a trifluorinated quinolone, in humans. Antimicrob Agents Chemother. 1987 Dec;31(12):1909-14.