CCT128930

产品说明书

Print
Chemical Structure| 885499-61-6 同义名 : -
CAS号 : 885499-61-6
货号 : A315162
分子式 : C18H20ClN5
纯度 : 95%
分子量 : 341.84
MDL号 : MFCD13177916
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(102.39 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Akt2

    Akt2, IC50:6 nM
描述 CCT128930 is a potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM and > 28-fold selectivity for Akt2 than the closely related PKA kinase.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
PC3M cells Function assay Inhibition of PKB in human PC3M cells assessed as GSK3-beta phosphorylation by ELISA, IC50=0.003 μM 20151677
U87MG cells Function assay Inhibition of PKB in human U87MG cells assessed as GSK3-beta phosphorylation by ELISA, IC50=0.66 nM 20151677
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.63mL

2.93mL

1.46mL

29.25mL

5.85mL

2.93mL
参考文献

[1]Yap TA, Walton MI, et al. AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. Clin Cancer Res. 2012 Jul 15;18(14):3912-23.

[2]Yap TA, Walton MI, et al. Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930. Mol Cancer Ther. 2011 Feb;10(2):360-71.