同义名 :	GTN; (R)-(+)-Goniothalamin; (6R)-(+)-Goniothalamin; Goniothalamine
	CAS号 :	17303-67-2
	货号 :	A311132
	分子式 :	C13H12O2
	纯度 :	98+%
	分子量 :	200.23
	MDL号 :	N/A
	存储条件：	Pure form In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Goniothalamin, a natural product isolated and purified from the herbs of Goniothalamus griffithii, enhances rather than inhibits the ATPase activity of a cyanobacterial Hsp90 (HtpG) and a yeast Hsp90, increases both K(m) and k(cat) of the Hsp90s. Goniothalamin has gastroprotective activity which is inhibited after pre-treatment with NEM (N-ethylmaleimide) and NSAID (non-steroidal anti-inflammatory drugs), and induces apoptosis in various cancer cell lines.

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	4.99mL 1.00mL 0.50mL	24.97mL 4.99mL 2.50mL	49.94mL 9.99mL 4.99mL

参考文献
[1]Yokoyama Y, Ohtaki A, et al. Goniothalamin enhances the ATPase activity of the molecular chaperone Hsp90 but inhibits its chaperone activity. J Biochem. 2015 Mar;157(3):161-8. [2]Yen HK, Fauzi AR, et al. Involvement of Seladin-1 in goniothalamin-induced apoptosis in urinary bladder cancer cells. BMC Complement Altern Med. 2014 Aug 9;14:295.