Pyrroloquinoline quinone

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Chemical Structure| 72909-34-3 同义名 : PQQ; Methoxatin; PQQ cofactor; PQQ coenzyme; Coenzyme PQQ
CAS号 : 72909-34-3
货号 : A309883
分子式 : C14H6N2O8
纯度 : 97%
分子量 : 330.21
MDL号 : MFCD00043125
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(3.03 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(3.03 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Pyrroloquinoline quinone, functioning as a redox co-factor, is characterized by its anionic nature and its ability to undergo redox cycling as an orthoquinone. Pyrroloquinoline quinone is procured from the cultures of methylotrophic bacteria and mammalian tissues. Pyrroloquinoline quinone is recognized as a vital nutrient for mammals, playing a crucial role in supporting immune functions[1][2].. Offspring of mice that are deprived of Pyrroloquinoline quinone (PQQ) during gestation and lactation exhibit impaired immune responses. Additionally, these pups display symptoms such as alopecia, a tendency to adopt a hunched posture, and a heightened risk of developing aortic aneurysms[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.03mL

0.61mL

0.30mL

15.14mL

3.03mL

1.51mL

30.28mL

6.06mL

3.03mL
参考文献

[1]Moog RS, et al. Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy. Proc Natl Acad Sci U S A. 1986 Nov;83(22):8435-9.

[2]Bishop A, et al. Methoxatin (PQQ) in guinea-pig neutrophils. Free Radic Biol Med. 1994 Oct;17(4):311-20.