Pralidoxime chloride

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Chemical Structure| 51-15-0 同义名 : 氯解磷定;1-甲基吡啶-2-醛肟氯鎓盐;1-甲基吡啶-2-醛肟氯盐;吡啶醛肟甲氯 ;2-PAM chloride; Pralidoxime (chloride); 2-PAM; 2-PAM (chloride)
CAS号 : 51-15-0
货号 : A307244
分子式 : C7H9ClN2O
纯度 : 98%
分子量 : 172.61
MDL号 : MFCD00011981
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 20 mg/mL(115.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(579.33 mM)
生物活性
描述 Pralidoxime Chloride is an oxime AChE (acetylcholinesteras) reactivator. Pralidoxime 100μM reversed human BuChE inhibition by parathion and by paraoxon by about 50%. Moreover, pralidoxime-induced reactivation of BuChE (butyrylcholinesterase) is highly variable, according to the dose, organophosphorus involved, and the individual poisoned[3]. In fact, a decrease in AChE activity of ~10 to 15% percent activity was observed between the 2-PAM Cl (Pralidoxime Chloride)-treated and untreated aldicarb and methomyl challenged gpAChE-R[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.79mL

1.16mL

0.58mL

28.97mL

5.79mL

2.90mL

57.93mL

11.59mL

5.79mL
参考文献

[1]Lucyk S, Vilensky D, et al. Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicol Sci. 2014 Apr;138(2):482.

[2]Rios JC, Repetto G, et al. High concentrations of pralidoxime are needed for the adequate reactivation of human erythrocyte acetylcholinesterase inhibited by dimethoate in vitro. Toxicol In Vitro. 2005 Oct;19(7):893-7.

[3]Konickx LA, Worek F, Jayamanne S, Thiermann H, Buckley NA, Eddleston M. Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicol Sci. 2013 Dec;136(2):274-83.

[4]Brittain MK, McGarry KG, Moyer RA, Babin MC, Jett DA, Platoff GE Jr, Yeung DT. Efficacy of Recommended Prehospital Human Equivalent Doses of Atropine and Pralidoxime Against the Toxic Effects of Carbamate Poisoning in the Hartley Guinea Pig. Int J Toxicol. 2016 May;35(3):344-57.