CP-91149

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Chemical Structure| 186392-40-5 同义名 : -
CAS号 : 186392-40-5
货号 : A305387
分子式 : C21H22ClN3O3
纯度 : 98+%
分子量 : 399.87
MDL号 : MFCD00954145
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(262.58 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Phosphorylase

    Glycogen phosphorylase (GP), IC50:0.13 μM
描述 CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.50mL

2.50mL

1.25mL

25.01mL

5.00mL

2.50mL
参考文献

[1]Aiston S, Hampson L, et al. Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis. J Biol Chem. 2001 Jun 29;276(26):23858-66.

[2]Martin WH, Hoover DJ, et al. Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1776-81.