Epinastine HCl

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Chemical Structure| 108929-04-0 同义名 : WAL801 hydrochloride; Epinastine (hydrochloride); WAL 801CL; WAL-801CL HCl; Epinastine hydrochloride
CAS号 : 108929-04-0
货号 : A303363
分子式 : C16H16ClN3
纯度 : 99%
分子量 : 285.77
MDL号 : MFCD00933434
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(174.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(349.93 mM)，配合低频超声助溶
生物活性
靶点

  • Histamine receptor
描述 Epinastine hydrochloride is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01569191 Hypersensitivity Phase 4 Completed - United Kingdom ... 展开 >> National Pollen and Aerobiology Unit Worcester, United Kingdom, WR2 6AJ 收起 <<
NCT01569191 - Completed - -
NCT01363700 Allergic Conjunctivitis Phase 3 Completed - Japan ... 展开 >> Santen study sites Osaka, Japan 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.50mL

0.70mL

0.35mL

17.50mL

3.50mL

1.75mL

34.99mL

7.00mL

3.50mL
参考文献

[1]Fujishima H, Ohashi Y, et al. Efficacy of epinastine hydrochloride ophthalmic solution in allergic conjunctivitis by conjunctival cedar pollen allergen challenge. Ann Allergy Asthma Immunol. 2014 Oct;113(4):476-81.

[2]Fugner A, Bechtel WD, et al. In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung. 1988 Oct;38(10):1446-53.