Citalopram HBr

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Chemical Structure| 59729-32-7 同义名 : 氢溴酸西酞普兰 ;Lu 10-171; (±)-Citalopram hydrobromide; Nitalapram; Lu 10-171B; Bonitrile; Citalopram (hydrobromide); Lu 10-171 HBr; Bonitrile HBr; Prepram HBr; Nitalapram HBr; Citalopram hydrobromide
CAS号 : 59729-32-7
货号 : A300817
分子式 : C20H22BrFN2O
纯度 : 98%
分子量 : 405.3
MDL号 : MFCD02101306
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(98.69 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(24.67 mM)，配合低频超声助溶
生物活性
靶点

  • 5-HT

    serotonin reuptake, IC50:1.8 nM
描述 Citalopram hydrobromide, a selective serotonin reuptake inhibitor (SSRI), blocks the uptake of 5-HT into synaptosomes with an IC50 of 1.8 nM and into rabbit blood platelets with an IC50 of 14 nM, displaying antidepressant effects[1].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00363909 Breast Cancer ... 展开 >> Hot Flashes Psychosocial Effects of Cancer and Its Treatment 收起 << Phase 3 Completed - -
NCT03429075 Depressive Disorder, Major Phase 2 Not yet recruiting December 2020 -
NCT00708240 Obsessive Compulsive Disorder Phase 4 Unknown December 2010 Canada, Ontario ... 展开 >> University of Ottawa Institute of Mental Health Research Recruiting Ottawa, Ontario, Canada, K1Z7K4 Contact: Zul Merali, PhD    613-722-6521 ext 6551    zul.merali@rohcg.on.ca    Principal Investigator: Martine F. Flament, MD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.34mL

2.47mL

1.23mL

24.67mL

4.93mL

2.47mL
参考文献

[1]J Hyttel. Citalopram--pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity. Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(3):277-95.

[2]Laurent Sakka, et al. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Oncotarget. 2017 Jun 27;8(26):42789-42807.

[3]F Pollier, et al. Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality. Neuropsychopharmacology. 2000 Jan;22(1):64-76.