4',7-Dimethoxyisoflavone

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Chemical Structure| 1157-39-7 同义名 : 4',7-二甲氧基-异磺酮 ;Dimethoxydaidzein
CAS号 : 1157-39-7
货号 : A299621
分子式 : C17H14O4
纯度 : 97%
分子量 : 282.29
MDL号 : MFCD00075889
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(177.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Telomerase
描述 4',7-Dimethoxyisoflavone is isolated from the leaves of Albizzia lebbeck, which shows antifungal activity. 4',7-Dimethoxyisoflavone shows antifungal activity against some plant pathogenic fungi tested in vitro, and the sensitivity of different fungi to this chemical varied considerably[2]. Daidzein, genistein, biochanin A, formononetin, 3-(2',4'-dichlorophenyl) -7-hydroxy-4H-chromen-4-one (DCHC), 7-hydroxy-4H-chromen-4-one (7-C), 4'7-dimethoxyisoflavone (4',7-D), and 5,7,4'-trimethoxyisoflavone (5,7,4'-T) increased peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha expression and resulted in mitochondrial biogenesis as indicated by increased expression of ATP synthase beta and ND6, and 1.5-fold increases in respiration and ATP in RPTC (renal proximal tubular cell)[3]. 4',7-dimethoxyisoflavone showed lower inhibitory effects for inhibitory effects on rat prostate testosterone 5α-reductase[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.54mL

0.71mL

0.35mL

17.71mL

3.54mL

1.77mL

35.42mL

7.08mL

3.54mL
参考文献

[1]Pandey MK, Pandey1 K, et al. Antifungal Activity of 4',7-Dimethoxyisoflavone Against Some Fungi. Mycobiology 30(1): 55-56 (2002).

[2]Nazir N, Koul S, Qurishi MA, Taneja SC, Purnima B, Qazi GN. New isoflavones from Iris kashmiriana. J Asian Nat Prod Res. 2008;10(11-12):1137‐1141

[3]Rasbach KA, Schnellmann RG. Isoflavones promote mitochondrial biogenesis. J Pharmacol Exp Ther. 2008;325(2):536‐543

[4]Bae M, Woo M, Kusuma IW, Arung ET, Yang CH, Kim YU. Inhibitory effects of isoflavonoids on rat prostate testosterone 5α-reductase. J Acupunct Meridian Stud. 2012;5(6):319‐322