Opicapone

产品说明书

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Chemical Structure| 923287-50-7 同义名 : BIA 9-1067
CAS号 : 923287-50-7
货号 : A297021
分子式 : C15H10Cl2N4O6
纯度 : 99%+
分子量 : 413.17
MDL号 : MFCD19443745
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(254.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Opicapone (BIA 9-1067) serves as a potent third-generation catechol-O-methyltransferase (COMT) inhibitor, primarily utilized in Parkinson's disease and motor fluctuation research. It reduces cellular ATP content with an IC50 of 98 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.42mL

0.48mL

0.24mL

12.10mL

2.42mL

1.21mL

24.20mL

4.84mL

2.42mL
参考文献

[1]Bonifácio MJ, et al. Pharmacological profile of Opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat. Br J Pharmacol. 2015 Apr;172(7):1739-52.

[2]Tahara A, et al. Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia, hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and obesity in type 2 diabetic mice. Eur J Pharmacol. 2013 Sep 5;715(1-3):246-55.