Gambogenic acid

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Chemical Structure| 173932-75-7 同义名 : -
CAS号 : 173932-75-7
货号 : A294508
分子式 : C38H46O8
纯度 : 98+%
分子量 : 630.77
MDL号 : MFCD32173486
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(166.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • FGFR
描述 Gambogenic acid binds to Cys668 within the EZH2-SET domain, triggering EZH2 degradation through COOH terminus of Hsp70‐interacting protein (CHIP)‐mediated ubiquitination.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.59mL

0.32mL

0.16mL

7.93mL

1.59mL

0.79mL

15.85mL

3.17mL

1.59mL
参考文献

[1]Wang X, Cao W, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 Mar 20. pii: e201694058.

[2]Chen R, Zhang H, et al. Gambogenic acid synergistically potentiates bortezomib-induced apoptosis in multiple myeloma. J Cancer. 2017 Mar 7;8(5):839-851.